AZD-9291,1421373-65-0

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YZ剂描述：

产品名称：AZD-9291

产品别名：EGFR inhibitor; AZD9291; AZD 9291;Tagrisso;Osimertinib; Mereletinib

英文别名：EGFR inhibitor;AZD9291;AZD 9291;Tagrisso;Osimertinib;Mereletinib

靶点：L858R/T790M EGFR ,Exon 19 deletion EGFR ,WT EGFR

CAS：1421373-65-0

纯度：>98%

外观：Powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：

AZD-9291 is a potent and selective mutated forms EGFR inhibitor(Exon 19 deletion EGFR IC50=12.92 nM, L858R/T790M EGFR IC50= 11.44 nM, wild type EGFR IC50= 493.8 nM).

溶解性：DMSO ：99 mg/mL warmed (198.15 mM)
Ethanol：43 mg/mL warmed (86.06 mM)

体外研究：

AZD9291 shows significantly more potent inhibition of proliferation in mutant EGFR cell lines compared to wild-type in vitro.

体内研究：AZD9291(5mg/kg p.o.) causes profound regression of tumors across EGFRm+ (PC9) and EGFRm+/T790M (H1975) tumor models with profound inhibition of EGFR phosphorylation and key downstream signaling pathways such as AKT and ERK in vivo.

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