AZ191,1594092-37-1

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

YZ剂描述：

产品名称：AZ191

产品别名：AZ-191,AZ 191

英文别名：AZ-191;AZ 191

靶点：DYRK1B ,DYRK1A

CAS：1594092-37-1

纯度：>98%

外观：Powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：AZ191 is a potent and selective DYRK1B inhibitor with IC50 of 17 nM, about 5- and 110-fold selectivity over DYRK1A and DYRK2, respectively.

溶解性：DMSO86 mg/mL (200.22 mM)
Ethanol1 mg/mL (2.32 mM)

体外研究：

AZ191 selectively inhibits DYRK1B serine/threonine kinase activity with no effect on tyrosine kinase autophosphorylation. In HEK-293 cells, AZ191 also displays much greater potency for DYRK1B over DYRK1A, inhibiting CCND1 phosphorylation. In HD1B cells, AZ191 strongly inhibits the levels of the cell-cycle regulators, p21Cip1 and p27Kip1, and increases cell-cycle progression.

体内研究：

产品信息订购：

产品更多信息请进入爱必信网站咨询