Anacardic Acid,16611-84-0

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

YZ剂描述：

产品名称：Anacardic Acid

产品别名：漆树酸

英文别名：Hydroginkgolic acid;6-pentadecylsalicylic Acid

靶点：Tip60；PCAF(p300/CREB-binding protein-associated factor) ；p300/CBP

CAS：16611-84-0

纯度：≥98%

外观：white to off-white solid

保存方法：Store at -20° C

描述：

Anacardic Acid is a potent inhibitor of p300 and p300/CBP-associated factor histone acetyltranferases, which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.

溶解性：DMSO ：69 mg/mL (197.98 mM)

体外研究：

Anacardic acid is found to be a common inhibitor of several clinically targeted enzymes such as NFkB kinase, histone acetyltransferase (HATs), lipoxygenase (LOX-1), xanthine oxidase, tyrosinase and ureases. Anacardic acid is also an efficient inhibitor of Tip60 in vitro.It inhibits the Tip60-dependent acetylation and activation of the ATM protein kinase in HeLa cells, and sensitizes the cells to the cytotoxic effects of radiation. Anacardic acid can effectively prevent cell damage induced by H2O2 because this can be converted to ROS, hydroxyl radicals, in the presence of metal ions.

体内研究：Anacardic acid attenuates over-expression of Gata4, α-MHC and cTnT in fetal mouse hearts exposed to ethanol. Anacardic acid inhibits binding of P300, PCAF to the promoter of Gata4.

产品信息订购：

产品更多信息请进入爱必信网站咨询