Bromosporine,1619994-69-2

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YZ剂描述：

产品名称：Bromosporine

产品别名：见爱必信官网

英文别名：Bromosporine

靶点：CECR2 ，BRD9 ，BRD4 ，BRD2

CAS：1619994-69-2

纯度：>98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Bromosporine is a broad spectrum inhibitor for bromodomains with IC50 of 0.41 μM, 0.29 μM, 0.122 μM and 0.017 μM for BRD2, BRD4, BRD9 and CECR2, respectively.

溶解性：DMSO Solubility: 81 mg/mL (200.27 mM)

体外研究：

In cell-based assays, Bromosporine (1 µM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 µM. Bromosporine shows moderate cytotoxicity in HeLa cells at 18 µM. Bromosporine, as a chemical probe for bromodomain functional assays, will be very useful in elucidating further biological roles of reader domains.

体内研究：

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