CPI-169,1450655-76-1

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YZ剂描述：

产品名称：CPI-169

产品别名：1-(1-(1-(ethylsulfonyl)piperidin-4-yl)ethyl)-N-((4-methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2- methyl-1H-indole-3-carboxamide

英文别名：racemate

靶点：EZH2 WT ，EZH2 Y641N ，EZH1

CAS：1450655-76-1

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

CPI-169 is a potent, and selective <b>EZH2</b> inhibitor with <b>IC50</b> of 0.24 nM, 0.51 nM, and 6.1 nM for EZH2 WT, EZH2 Y641N, and EZH1, respectively.

溶解性：DMSO ：100mg/mL(189.15mM)
Ethanol ：100mg/mL(189.15mM)

体外研究：

In KARPAS-422 cells, CPI-169 shows a dose-dependent inhibitory effect on cell viability, and produces synergy anti-proliferative activity when used in combination with ABT-199. In 16 out of 25 NHL cell lines, CPI-169 also suppresses cell growth with GI50 of

体内研究：In mice bearing KARPAS-422 xenografts, CPI-169 (200 mg/kg, s.c.) effectively suppresses H3K27me3 levels and results in lymphoma tumor regression without affecting body weight or causing any overt adverse effects.

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