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体外研究: Cyclo(-RGDfK) is a potent and selective inhibitor of the αvβ3 integrin, with a IC50 of 0.94 nM. DOTA-E-2 can be prepared with high radiochemical purity (>97%), specific activity (36-67GBq/μM), in vitro stability, and moderate protein binding. MicroPET imaging up to 24 post-injection showed contrasting tumors reflecting αvβ3-targeted tracer accumulation. 体内研究:在负荷α(v)β(3)-整合素-阳性C6神经胶质瘤的无胸腺小鼠中,Cyclo (-RGDfK-)修饰诱导更少的肿瘤发生,更低的肿瘤代谢活性,和更少的瘤内血管。 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs810192 | cyclo(-RGDfK) | 5mg | 1077 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |