McMMAF,863971-19-1_详细资料

产品信息

货号： abs822859 CAS号： 863971-19-1 供应商：爱必信(上海) 生物科技有限公司数量： 99 保质期：见爱必信官网保存条件： store at -20℃ for one year（Powder）规格： 1mg

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YZ剂描述：
产品名称：McMMAF
产品别名：见爱必信官网
英文别名：McMMAF
靶点：ADC Linker
CAS：863971-19-1
纯度：98%
外观：见爱必信官网
保存方法：store at -20℃ for one year（Powder）
描述：Mc-MMAF is a protective group-conjugated MMAF. MMAF is a more potent drug than Monomethyl auristatin E (MMAE), but is charged and relatively membrane-impermeable, is a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.Target:MMAF is a new auristatin derivative with a charged C-terminal phenylalanine that attenuates its cytotoxic activity compared to its uncharged counterpart, Monomethyl auristatin E (MMAE). Because of MMAF is highly toxic, it cannot be used as a drug itself. MMAF induces potent antitumor effects when conjugated via protease cleavable linkers to a monoclonal antibody targeting internalizing, tumor-specific cell surface antigens. The linker to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the anti-mitotic mechanism.
溶解性：
In Vitro:
DMSO : ≥ 100 mg/mL (108.09 mM)
* "≥" means soluble, but saturation unknown.
Preparing
Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.0809 mL 5.4045 mL 10.8089 mL
5 mM 0.2162 mL 1.0809 mL 2.1618 mL
10 mM 0.1081 mL 0.5404 mL 1.0809 mL
*请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存方式和期限。
In Vivo:
请根据您的实验动物和给YF式选择适当的溶解方案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的工作
液，建议您现用现配，当天使用；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比)：
1.
请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline
Solubility: ≥ 5 mg/mL (5.40 mM); Clear solution
2.
请依序添加每种溶剂： 10% DMSO    90% corn oil
Solubility: ≥ 5 mg/mL (5.40 mM); Clear solution
*
体外研究：
体内研究：
产品信息订购：

  产品货号   产品名称   规格价格大包装及货期

  abs822859   McMMAF   1mg   6600   立即咨询

产品更多信息请进入爱必信网站咨询

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