CCT251236,1693731-40-6_详细资料

产品信息

货号： abs821128 CAS号： 1693731-40-6 供应商：爱必信(上海) 生物科技有限公司数量： 99 保质期：见爱必信官网保存条件： store at -20℃ for one year（Powder）规格： 1mg

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YZ剂描述：
产品名称：CCT251236
产品别名：见爱必信官网
英文别名：CCT251236
靶点：HSP
CAS：1693731-40-6
纯度：98%
外观：见爱必信官网
保存方法：store at -20℃ for one year（Powder）
描述：CCT251236 is an orally available pirin ligand from a heat shock transcription factor 1 (hsf1) phenotypic screen with an IC50 of 19 nM for inhibition of HSF1-mediated HSP72 induction.
溶解性：
In Vitro:
DMSO : ≥ 150 mg/mL (271.43 mM)
* "≥" means soluble, but saturation unknown.
Preparing
Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.8096 mL 9.0478 mL 18.0956 mL
5 mM 0.3619 mL 1.8096 mL 3.6191 mL
10 mM 0.1810 mL 0.9048 mL 1.8096 mL
*请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存方式和期限。
In Vivo:
请根据您的实验动物和给YF式选择适当的溶解方案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的工作
液，建议您现用现配，当天使用；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比)：
1.
请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline
Solubility: ≥ 2.5 mg/mL (4.52 mM); Clear solution
*
体外研究：
CCT251236 displays the desired balance of in vitro properties, while maintaining excellent cellular activity with an IC50 of 19 nM. The free GI50 in SK-OV-3 cells is 1.1 nM. Western blotting confirms that CCT251236 blocks the HSF1-mediated induction of both HSP72 and HSP27 as representative heat shock proteins, following treatment with the HSP90 inhibitor 17AAG. Also, qPCR analysis demonstrates that CCT251236 inhibits the induction of HSP72 at the mRNA level, clearly blocking the induction of HSPA1A gene expression with an IC50 of 40 nM.
体内研究：CCT251236 displays the desired balance of in vitro properties, while maintaining excellent cellular activity with an IC50 of 19 nM. The free GI50 in SK-OV-3 cells is 1.1 nM. Western blotting confirms that CCT251236 blocks the HSF1-mediated induction of both HSP72 and HSP27 as representative heat shock proteins, following treatment with the HSP90 inhibitor 17AAG. Also, qPCR analysis demonstrates that CCT251236 inhibits the induction of HSP72 at the mRNA level, clearly blocking the induction of HSPA1A gene expression with an IC50 of 40 nM.
产品信息订购：

  产品货号   产品名称   规格价格大包装及货期

  abs821128   CCT251236   1mg   1320   立即咨询

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