LEE011,1211441-98-3

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

YZ剂描述：

产品名称：LEE011

产品别名：7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide

英文别名：LEE 011;LEE-011;Ribociclib;LEE011

靶点：CDK

CAS：1211441-98-3

纯度：>98%

外观：Powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：

LEE011 is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity.

溶解性：DMSO：7 mg/mL (16.1 mM)

体外研究：

LEE011是一种CDK4/CDK6的双重YZ剂，能够显著YZ17种神经细胞瘤中的12种的生长，平均IC50值是307 nM。对神经细胞瘤的YZ主要是YZ细胞的生长，受到G1细胞周期阻滞和细胞衰老的调控。

体内研究：CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with LEE011 (200 mg/kg) or with a vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models. Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p.

产品信息订购：

产品更多信息请进入爱必信网站咨询