Vardenafil dihydrochloride,224789-15-5

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产品名称：Vardenafil dihydrochloride

产品别名：见爱必信官网

英文别名：Vardenafil dihydrochloride

靶点：PDE1,180 nM (Cell-free)

CAS：224789-15-5

纯度：见爱必信官网

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：Vardenafil dihydrochloride is a new type PDE inhibitor with IC50 of 0.7 and 180 nM for PDE5 and PDE1, respectively.

溶解性：

Ethanol: 16 mg/mL (27.6 mM)

Water: 10 mg/mL (17.27 mM)

DMSO: 93 mg/mL (160.6 mM)

（ < 1 mg/ml refers to the product slightly soluble or insoluble )

体外研究：

Vardenafil specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). Vardenafil significantly enhances the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiates both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle. Vardenafil (100 mM) increases cyclic GMP levels in rat hippocampal slices. Vardenafil, tadalafil, and Sildenafil each competitively inhibit cGMP hydrolysis by phosphodiesterase-5 (PDE5), thereby fostering cGMP accumulation and relaxation of vascular smooth muscle.

体内研究：Vardenafil specifically inhibits the hydrolysis of cGMP by PDE5 with an IC50 of 0.7 nM (6.6 nM). Vardenafil significantly enhances the SNP-induced relaxation of human trabecular smooth muscle at 3 nM (10 nM). Vardenafil also significantly potentiates both ACh-induced and transmural electrical stimulation-induced relaxation of trabecular smooth muscle. Vardenafil (100 mM) increases cyclic GMP levels in rat hippocampal slices. Vardenafil, tadalafil, and Sildenafil each competitively inhibit cGMP hydrolysis by phosphodiesterase-5 (PDE5), thereby fostering cGMP accumulation and relaxation of vascular smooth muscle.

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