7-(Diethylamino)coumarin-3-carboxylic acid,50995-74-9

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产品名称：7-(Diethylamino)coumarin-3-carboxylic acid

产品别名：7-(二乙基氨基)香豆素-3-甲酸

英文别名：7ACC1;DEAC;Coumarin D 1421;D 1421

靶点：MCT

CAS：50995-74-9

纯度：>98%

外观：Orange solid

保存方法：Store at -20°C

描述：

7ACC1(DEAC; Coumarin D 1421; D 1421) selectively interfere with lactate fluxes in the lactate-rich tumor microenvironment; inhibits lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. IC50 value: 0.86 uM(Lactate uptake inhibition) [1] Target: MCT inhibitor; lactate transport inhibitor Contrary to the reference MCT1 inhibitor AR-C155858, 7ACC unexpectedly inhibited lactate influx but not efflux in tumor cells expressing MCT1 and MCT4 transporters. 7ACC delayed the growth of cervix SiHa tumors, colorectal HCT116 tumors, and orthoptopic MCF-7 breast tumors. MCT target engagement was confirmed by the lack of activity of 7ACC on bladder UM-UC-3 carcinoma that does not express functional MCT. 7ACC also inhibited SiHa tumor relapse after treatment with cisplatin. Finally, we found that contrary to AR-C155858, 7ACC did not prevent the cell entry of the substrate-mimetic drug 3-bromopyruvate (3BP) through MCT1, and contributed to the inhibition of tumor relapse after 3BP treatment. 

溶解性：DMSO : 32 mg/mL (122.48 mM; Need ultrasonic and warming)

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