CFTRinh 172 (CFTR Inhibitor-172),307510-92-5

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产品名称：CFTRinh 172 (CFTR Inhibitor-172)

产品别名：3-[(3-三氟甲基)苯基]-5-[(4-羧基苯基)亚甲基]-2-硫代-4-噻唑烷酮

英文别名：CFTR Inhibitor-172;CFTRinh-172

靶点：CFTR

CAS：307510-92-5

纯度：98%

外观：黄色粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：

Voltage-independent, selective CFTR chloride channel blocker (Ki = 300 nM) that alters channel gating.

溶解性：DMSO : 40.9 mg/mL (100 mM)

体外研究：

CFTRinh-172 dose- and time-dependently inhibits CFTR-mediated I- transportation, and effectively inhibits CFTR activation by multiple types of agonists or activators. CFTRinh-172, as a selective CFTR channel inhibitor, also completely abolishes the Cl− current in the rabbit acinar and duct cells of rabbit lacrimal gland. CFTRinh-172 also induces ROS production, mitochondrial failure, and activation of the NF-κB signaling pathway, independently of CFTR inhibition.

体内研究：CFTRinh-172 (20 µg/6 h) completely abolishes the V. cholerae-induced intestinal fluid secretion without affecting V. cholerae growth in vivo.

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