公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）! YZ剂描述： 产品名称：Taurolidine 产品别名：牛磺罗定 英文别名：Taurolin;Tauroline 靶点：Antibacterial CAS：19388-87-5 纯度：≥98% 外观：White to off-white powder. 保存方法：Store at -20° C 描述： Taurolidine is a synthetic taurine analog with antimicrobial and anti-neoplastic actions. Taurine, a conditionally-essential amino acid, is not utilized in protein synthesis, but is found free or in simple peptides. Taurine has been shown to be essential in mammalian development. In vitro studies have demonstrated that low levels of taurine are associated with various pathological lesions. 溶解性：DMSO ：56 mg/mL (196.93 mM) 体外研究： Previous study found that in selected human and murine tumor cell lines, a 3-day exposure to taurolidine could inhibit the growth of all of the cell lines. Further mechanistic study showed that in NIH-3T3 murine fibroblasts and the PA-1 and SKOV-3 human ovarian tumor cells, a 48-h exposure to taurolidine had little effect on cell cycle distribution in PA-1 and SKOV-3 cells but greatly increased the appearance of DNA debris, an effect consistent with an induction of apoptosis. In contrast, in NIH-3T3 cells, taurolidine exposure did not increase DNA debris in the sub-G(0)/G(1) region. 体内研究：Animal study found that the i.v. administration of 2% taurolidine and 3% taurolidine as well the i.p. application of 2% taurolidine could decrease the development of advanced i.p. tumor lesions. No changes of differential blood count nor relevant animal weight changes resulted. Moreover, taurolidine did not impair the liver tissue, kidneys, SVC, and leucopoiesis. The intravenous therapy of 2% taurolidine was found to be safe and anti-tumorigenic in advanced local tumor growth in rats. 产品信息订购： | 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | | abs814813 | Taurolidine | 500mg | 2310 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 | 
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