公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! YZ剂描述: 产品名称:Butenafine hydrochloride 产品别名:盐酸布替萘芬 英文别名:Butenafine hydrochloride 靶点:Antifungal CAS:101827-46-7 纯度:>98% 外观:白色结晶性粉末 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: Butenafine hydrochloride is a synthetic benzylamine antifungal, works by inhibiting the synthesis of sterols by inhibiting squalene epoxidase. 溶解性:Ethanol :65 mg/mL (184 mM) DMSO :65 mg/mL (184 mM) 体外研究: Butenafine HCl shows minimum inhibitory concentrations ranging from 0.03–1.0 µg/mL against 30 isolates representing different dermatophyte species. Butenafine shows limited activity against C. albicans and no activity against M. furfur against 10 isolates of two species of yeasts. Butenafine HCl shows activity against β-hemolytic Streptococcus Group A and Corynebacterium but failed to inhibit S. aureus against 25 isolates representing different Gram-positive bacteria species. Butenafine fails to show activity against any of the Gram-negative strains tested. Butenafine interferes with fungal ergosterol biosynthesis by inhibiting the conversion of squalene into squalene epoxide which is catalyzed by squalene epoxidase. Butenafine shows activity against KD-04 and KD-305 with minimum inhibitory concentrations of 12 ng/mL. 体内研究:Butenafine (1%, once daily) shows excellent efficacy against dermatophytosis in male hartley strain guinea pigs, and the effect is superior to those of naftifine, tolnaftate, clotrimazole, and bifonazole. Butenafine (1%) exhibits excellent prophylactic efficacy against experimental T. mentagrophytes infection when apply once at 24 or 48 h before infection. After 16 weeks, 80% of patients using medicated cream incorporating 2% butenafine HCl are cured, as opposed to none in the placebo group. Four patients in the active treatment group experience subjective mild inflammation without discontinuing treatment. During follow-up, no relapse occurres in cured patients and no improvement is seen in medication-resistant and placebo participants. Butenafine (1% cream) applied once daily for 4 weeks results in an effective clinical response and mycologic cure of tinea pedis during treatment in patients with positive fungal cultures. Butenafine hydrochloride (1% cream) alone is extremely effective for the treatment of hyperkeratotic-type tinea pedis patients. 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs813535 | Butenafine hydrochloride | 100mg | 844 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |