Valsartan,137862-53-4

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YZ剂描述：

产品名称：Valsartan

产品别名：缬沙坦

英文别名：CGP-48933

靶点：Angiotensin Receptor

CAS：137862-53-4

纯度：98%

外观：white crystalline powder

保存方法：-20°C

描述：

 Valsarta (CGP-48933) 是用于ZL高血压和心力衰竭的angiotensin II受体拮抗剂。

溶解性：Ethanol：87mg/mL(199.76mM)DMSO：87mg/ml(199.76 mM)Water<1mg/ml

体外研究：

Valsartan is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R in ageing aorta endothelial cells. The pretreatment of valsartan results in an inhibition of TLR2 signaling and proinflammatory cytokines. The expression of AGTR1 is up-regulated after alcohol exposure, and is blocked by valsartan pretreatment.

体内研究：Valsartan significantly attenuates the expression of TGF-β/Smad, Hif-1α and fibrosis-related protein in rats after MI. Heart function, infarcted size, wall thickness as well as myocardial vascularization of ischaemic hearts are also significantly improved by valsartan compared with saline and hydralazine. Valsartan partially reverses the effects of high-salt diet on hypertension, cardiac injuries such as fibrosis and inflammatory cell infiltration, and inhibition of aquaporin 1 and angiogenic factors; valsartan alone does not exert such effects. Valsartan is an effective antidepressant/antianxiety reagent and can promote the hippocampal neurogenesis and expression of BDNF. Chronic administration of valsartan (5-40 mg/kg/d, p.o.) increases the time spent in the center of the field in OFT and the latency to eat in NSF, reduces the immobility time in both TST and FST, and increases the sucrose preference in SPT.

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