Isavuconazonium sulfate,946075-13-4

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YZ剂描述：

产品名称：Isavuconazonium sulfate

产品别名：见爱必信官网

英文别名：Isavuconazonium sulfate

靶点：inhibits the synthesis of ergosterol,

CAS：946075-13-4

纯度：98%

外观：见爱必信官网

保存方法：store at -20℃ for one year（Powder）

描述：Isavuconazonium sulfate is hydrolyzed by plasma esterases to yield the active moiety isavuconazole. Isavuconazole binds to and inhibits the fungal cytochrome P450 family enzyme lanosterol 14-alpha-demethylase (CYP51), which catalyzes the demethylation of lanosterol to yield ergosterol, an important component of the fungal cell membrane. Isavuconazonium Sulfate is a prodrug of the triazole antifungal agent isavuconazole, with broad-spectrum antifungal activity. Inhibition of CYP51 leads to a decrease in fungal ergosterol production and disrupts the synthesis of the fungal cell membrane, which decreases membrane integrity, increases cell membrane permeability and promotes the loss of essential intracellular elements. This results in fungal cell lysis and death.

溶解性：

（ < 1 mg/ml refers to the product slightly soluble or insoluble )

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