Ibiglustat L-Malic acid,1629063-78-0_详细资料

产品信息

货号： abs821053 CAS号： 1629063-78-0 供应商：爱必信(上海) 生物科技有限公司数量： 99 保质期：见爱必信官网保存条件： store at -20℃ for one year（Powder）规格： 2mg

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YZ剂描述：
产品名称：Ibiglustat L-Malic acid
产品别名：见爱必信官网
英文别名：Ibiglustat L-Malic acid
靶点：Glucosylceramide synthase.
CAS：1629063-78-0
纯度：98%
外观：见爱必信官网
保存方法：store at -20℃ for one year（Powder）
描述：Ibiglustat L-Malic acid (Venglustat L-Malic acid), a potential therapy for PD Parkinson’s disease, SRT in Fabry’s and Gaucher’s, is a selective, allosteric inhibitor of glucosylceramide synthase (GCS) with ability to cross the blood-brain barrier.
溶解性：
In Vitro:
DMSO : ≥ 102 mg/mL (194.82 mM)
* "≥" means soluble, but saturation unknown.
Preparing
Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.9100 mL 9.5498 mL 19.0996 mL
5 mM 0.3820 mL 1.9100 mL 3.8199 mL
10 mM 0.1910 mL 0.9550 mL 1.9100 mL
*请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存方式和期限。
体外研究：
Ibiglustat (SAR402671) (1 μM, 15 days) treated FD cells are close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes.
体内研究：Ibiglustat (SAR402671) (1 μM, 15 days) treated FD cells are close to the physiological level in untreated WT cells in GL-3 levels, suggesting that Ibiglustat can prevent additional GL-3 accumulation and could serve to ameliorate the abundant levels of this sphingolipid in FD cardiomyocytes.
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