DDP-38003 dihydrochloride,1831167-98-6

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产品名称：DDP-38003 dihydrochloride

产品别名：见爱必信官网

英文别名：DDP-38003 dihydrochloride

靶点：Histone Demethylase

CAS：1831167-98-6

纯度：见爱必信官网

外观：见爱必信官网

保存方法：见爱必信官网

描述：DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.

溶解性：DMSO: ≥ 29 mg/mL

体外研究：

DDP-38003 inhibits KDM1A with an IC₅₀ of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue.

体内研究：

DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent.

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