GSK2141795 hydrochloride,1047635-80-2

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

YZ剂描述：

产品名称：GSK2141795 hydrochloride

产品别名：见爱必信官网

英文别名：N-[(2S)-1-amino-3-(3,4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-2-methylpyrazol-3-yl)furan-2-carboxamide,hydrochloride

靶点：Akt

CAS：1047635-80-2

纯度：见爱必信官网

外观：见爱必信官网

保存方法：见爱必信官网

描述：Uprosertib hydrochloride (GSK2141795 hydrochloride) is a potent and selective pan-Akt inhibitor with IC50 values of 180/328/38 nM for Akt1/Akt2/Akt3, respectively.

溶解性：10 mM in DMSO

体外研究：

Uprosertib inhibits Akt1/2/3 with the K_d values of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding.

体内研究：

产品信息订购：

产品更多信息请进入爱必信网站咨询