PF-06380101,1436391-86-4

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

YZ剂描述：

产品名称：PF-06380101

产品别名：见爱必信官网

英文别名：PF-06380101

靶点：Microtubule/Tubulin

CAS：1436391-86-4

纯度：见爱必信官网

外观：见爱必信官网

保存方法：见爱必信官网

描述：见爱必信官网

溶解性：DMSO: ≥ 65 mg/mL

体外研究：

体内研究：

After an IV dose of 20a at 20 μg/kg to Wistar Han rats, PF-06380101 exhibited a mean systemic clearance (Cl) of 70 mL/min/kg and a volume of distribution (Vss) of 14.70 L/kg, resulting in a terminal elimination half-life (t1/2) of approximately 6 h. PF-06380101 preferentially distributes into human plasma relative to whole blood and that PF-06380101 is a P-glycoprotein (P-gp) substrate. PF-06380101 is anticipated to be of low risk to perpetrate pharmacokinetic drug interactions with compounds for which CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and/or CYP3A4/5-mediated metabolism constitutes the primary mechanism of clearance. The utility of the new auristatin analogues as ADC payloads including the development of the lead analogue 20a (PF-06380101) will be reported in due course.

产品信息订购：

产品更多信息请进入爱必信网站咨询