Tenofovir Alafenamide Hemifumarate,1392275-56-7_详细资料

产品信息

货号： abs814224 CAS号： 1392275-56-7 供应商：爱必信(上海) 生物科技有限公司数量： 99 英文名： Tenofovir alafenamide; GS7340; GS 7340 保质期：见爱必信官网保存条件： store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 规格： 100mg

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YZ剂描述：
产品名称：Tenofovir Alafenamide Hemifumarate
产品别名：替诺福韦艾拉酚胺半富马酸盐
英文别名：Tenofovir alafenamide;GS7340;GS 7340
靶点：Reverse Transcriptase
CAS：1392275-56-7
纯度：>98%
外观：Powder
保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.
描述：GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.
溶解性：
In Vitro:
DMSO : 50 mg/mL (93.55 mM; Need ultrasonic)
Preparing
Stock Solutions
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 1.8709 mL 9.3545 mL 18.7091 mL
5 mM 0.3742 mL 1.8709 mL 3.7418 mL
10 mM 0.1871 mL 0.9355 mL 1.8709 mL
*请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液，并请注意储备液的保存方式和期限。
In Vivo:
请根据您的实验动物和给YF式选择适当的溶解方案，配制前请先配制澄清的储备液，再依次添加助溶剂(为保证实验结果的可靠性，体内实验的工作
液，建议您现用现配，当天使用；澄清的储备液可以根据储存条件，适当保存；以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比)：
1.
请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% saline
Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution
2.
请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (4.68 mM); Clear solution
3.
请依序添加每种溶剂： 10% DMSO    90% corn oil
Solubility: 2.5 mg/mL (4.68 mM); Clear solution; Need warming
*
体外研究：
Tenofovir disoproxil fumarate (TDF) serves as a control for CatA-independent prodrug activation. Baseline antiviral activities (mean EC50±standard deviation) obtained in the absence of a protease inhibitors (PI) are determined from 6 independent donors for GS-7340 (EC50=5.3±1.2 nM) and TDF (EC50=2.8±1.1 nM) and are used to calculate fold change EC50s from four independent donors under conditions of PI pretreatment. GS-7340 antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC50s range from 0.1 to 12 nM, with a mean EC50 of 3.5 nM compared to a mean EC50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC50s are 1.8 nM for TAF and 6.4 nM for AZT.
体内研究：GS-7340 is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF) .
产品信息订购：

  产品货号   产品名称   规格价格大包装及货期

  abs814224   Tenofovir Alafenamide Hemifumarate   100mg   3510   立即咨询

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