PBTZ169,1377239-83-2

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YZ剂描述：

产品名称：PBTZ169

产品别名：PBTZ169,PBTZ-169,PBTZ 169

英文别名：PBTZ169;PBTZ-169;PBTZ 169

靶点：Others

CAS：1377239-83-2

纯度：>98%

外观：Powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

PBTZ169 is a decaprenyl-phosphoribose-epimerase (DprE1) inhibitor.

溶解性：DMSO: 6.4 mg/mL (Need ultrasonic)

体外研究：

PBTZ169, inhibit decaprenylphosphoryl-β-d-ribose 2′-oxidase (DprE1) and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.

体内研究：PBTZ169 can be suspend in 0.25% hydroxy-propylmethyl-cellulose. The administertration for PBTZ169 is 100 mg/kg by gavage. The MIC50 and MIC90 values were 0.0075 and 0.030 μg/mL, respectively. The MIC for PBTZ169 for N. brasiliensis HUJEG-1 was 0.0037 μg/mL. PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB).

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