Leuprorelin Acetate,74381-53-6；53714-56-0(free base)

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产品名称：Leuprorelin Acetate

产品别名：醋酸亮丙瑞林

英文别名：Leuprorelin Acetate

靶点：GNRH Receptor

CAS：74381-53-6；53714-56-0(free base)

纯度：98%

外观：White powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Leuprolide is an agonist at pituitary GnRH receptors. Target: GnRH receptor Leuprorelin is a gonadotrophin-releasing hormone (GnRH) analogue used to treat a wide range of sex hormone-related disorders including advanced prostatic cancer, endometriosis and precocious puberty. Leuprorelin acts primarily on the anterior pituitary, inducing a transient early rise in gonadotrophin release. With continued use, Leuprorelin causes pituitary desensitisation and/or down-regulation, leading to suppressed circulating levels of gonadotrophins and sex hormones.  By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol and testosterone levels in both sexes. 

溶解性：DMSO ：100 mg/mL (78.77 mM)
Water ：100 mg/mL (78.77 mM)
Alcohol ：100 mg/mL (78.77 mM)

体外研究：

Leuprolide acetate is a synthetic nonapeptide that is a potent gonadotropin-releasing hormone receptor (GnRHR) agonist. Leuprolide acetate suppresses gonadotrope secretion of luteinizing hormone and follicle-stimulating hormone that subsequently suppresses gonadal sex steroid production.

体内研究：Leuprolide acetate is used for diverse clinical applications, including the treatment of prostate cancer, endometriosis, uterine fibroids, central precocious puberty and in vitro fertilization techniques. Leuprolide acetate is presently being tested for the treatment of Alzheimer's disease, polycystic ovary syndrome, functional bowel disease, short stature, premenstrual syndrome and even as an alternative for contraception. Leuprolide acetate is considered to be a very safe and tolerable drug.

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