Pheniramine Maleate,132-20-7

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产品名称：Pheniramine Maleate

产品别名：马来酸非尼拉敏

英文别名：Pheniramine Maleate

靶点：Histamine Receptor

CAS：132-20-7

纯度：>98%

外观：白色或类白色结晶性粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Pheniramine Maleate is an antihistamine with anticholinergic properties used to treat allergic conditions such as hay fever or urticaria.

溶解性：Ethanol ：66 mg/mL (185.2 mM)
DMSO ：66 mg/mL (185.2 mM)
Water ：65 mg/mL (182.4 mM)

体外研究：

Pheniramine Maleate is a histamine H1 antagonists with little sedative action. It is used in treatment of hay fever, rhinitis, allergic dermatoses, and pruritus. Pheniramine appears to compete with histamine for histamine H1- receptor sites on effector cells. The antihistamines antagonize those pharmacological effects of histamine which are mediated through activation of H1- receptor sites and thereby reduce the intensity of allergic reactions and tissue injury response involving histamine release. Antihistamines suppress the histamine-induced wheal (swelling) and flare (vasodilation) response by blocking the binding of histamine to its receptors on nerves, vascular smooth muscle, glandular cells, endothelium, and mast cells. They effectively exert competitive antagonism of histamine for H1-receptors.

体内研究：

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