Medetomidine hydrochloride,86347-15-1

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YZ剂描述：

产品名称：Medetomidine hydrochloride

产品别名：盐酸美托咪定

英文别名：MPV785

靶点：α2-adrenoceptor

CAS：86347-15-1

纯度：>98%

外观：白色或类白色结晶性粉末

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

Medetomidine is a selective α2-adrenoceptor agonist, with K_i of 1.08 nM, exhibts 1620-fold selectivity over α1-adrenoceptor.

溶解性：DMSO ：23.7 mg/mL (100 mM)
Water ：23.7 mg/mL (100 mM)

体外研究：

Medetomidine is a selectiveα2-adrenoceptor agonist, with Ki of 1.08 nM, exhibits 1620-fold selectivity over α1-adrenoceptor, has very weak or no binding to other neurotransmitter receptors.

体内研究：In anesthetized rats, medetomidine (1-100 μg/kg, i.v.) induces a dose-dependent, relatively short-lived reduction in blood pressure and heart rate. In the pithed rat, medetomidine shows very potent vasopressor (PD50 1.7 μg/kg) and sympatho-inhibitory (ID50 1.6 μg/kg) effects without affecting basal heart rate. Medetomidine induces dose-dependent sedation, which at high doses (>100μg/kg) includes loss of the righting reflex and hypothermia. Medetomidine induces a decreases in the turnover rate of biogenic amines in the brain, dose-dependently inhibits norepinephrine (NE) turnover, inhibits brain dopamine turnover at high doses, decreases serotonin turnover.

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