公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! YZ剂描述: 产品名称:Vilazodone hydrochloride 产品别名:盐酸维拉唑酮 英文别名:EMD 68843;SB659746A 靶点:SSRI ,5-HT1A CAS:163521-08-2 纯度:>98% 外观:白色结晶性粉末 保存方法:-20°C 冷藏长期储存,常温运输及临时存放 描述: KALA peptide binds oligonucleotides and disrupts cell membrane; therefore, it can be used as a DNA transfection reagent. 溶解性:DMSO :9.6 mg/mL (20 mM) 体外研究: Vilazodone demonstrates an IC50 of 0.2 nM at the human 5-HT1A receptor and 0.5 nM for the SERT. Vilazodone displays high affinity (pKi ≥ 9.3) for human recombinant and rat, guinea pig, mouse, and marmoset native tissue 5-HT1A receptors. 体内研究:Vilazodone selectively enhances serotonergic output in the prefrontal cortex of rats. Vilazodone demonstrates anxiolytic efficacy through Behavioral evaluations in the ultrasonic vocalization model of anxiety in rats. Vilazodone also shows efficacy but at a single dose only in the forced swim test (a putative model of depression). Vilazodone (1-10 mg/kg p.o.) dose-dependently displaces in vivo DASB (N,N-dimethyl-2-(2-amino-4-cyanophenylthio)benzylamine) binding from rat cortex and hippocampus, indicating that vilazodone occupies 5-HT transporters in vivo. Vilazodone (10 mg/kg p.o.) is demonstrated to cause a 2-fold increase in extracellular 5-HT but no change in noradrenaline or dopamine levels in frontal cortex of freely moving rats. Vilazodone affects stress potentiation of startle at doses above 5 mg/kg in rats. Vilazodone increases stress elevation of startle at 10 mg/kg in rats. Vilazodone (20 and 40 mg/kg) blocked stress potentiation of startle in rats. Vilazodone increases stress elevation of startle at all doses in rats. vilazodone has no effect on 5-HT efflux at 100 nM but significantly decreases 5-HT efflux at 1 mM in the guinea-pig dorsal raphe nucleus. Vilazodone significantly increases the re-uptake half life for 5-HT in the guinea-pig dorsal raphe nucleus. 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs813692 | Vilazodone hydrochloride | 10mg | 378 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |