Cardiogenol C hydrochloride,1049741-55-0

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YZ剂描述：

产品名称：Cardiogenol C hydrochloride

产品别名：Cardiogenol C HCl

英文别名：Cardiogenol C HCl

靶点：Wnt;β-catenin

CAS：1049741-55-0

纯度：98%

外观：solid

保存方法：Store at -20°C

描述：

Cardiogenol C hydrochloride is a cell-permeable pyrimidine compound which potently induces the differentiation of ESCs into cardiomyocytes (EC50= 100 nM). 

溶解性：DMSO : ≥ 59 mg/mL (198.82 mM)

体外研究：

Cardiogenol C hydrochloride is a cardiomyogenesis inducer in embryonic stem cells. Cardiogenol C induces the differentiation of myosin heavy chain-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 μM; about 90% of embryonic stem cells treated with 0.25 μM of Cardiogenol C express the cardiac muscle cell specific transcription factors GATA-4, MEF2, and Nkx2.5 and display the characteristic beating behavior of differentiated cardiomyocytes. Cardiogenol C (a diaminopyrimidine) induces cardiac differentiation in P19 and in P19Cl6 cells. Cardiogenol C could activate Wnt/β-catenin signaling to induce cardiogenesis. Cardiogenol C-treatment significantly decreased HBPCs proliferation. Cardiogenol C was able to induce HBPCs to transdifferentiate into cardiomyocyte-like cells.

体内研究：

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