BQR-695,1513879-21-4

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YZ剂描述：

产品名称：BQR-695

产品别名：NVP-BQR695

英文别名：NVP-BQR695

靶点：PI4K

CAS：1513879-21-4

纯度：98%

外观：见爱必信官网

保存方法：-20℃

描述：

BQR-695 is a phosphatidylinositol 4-kinase (PI4K) inhibitor with IC50s of 80 and 3.5 nM for human PI4KIIIβ and Plasmodium variant of PI4KIIIβ, respectively.

溶解性：DMSO ：100 mg/mL

体外研究：

Treatment with 0.5 μM of either KAI407 or BQR695 causes GFP-PHOsh2 to redistribute to the parasite plasma membrane, consistent with depletion of intracellular PI4P upon inhibition of PfPI4K function. BQR695 shows no evidence of toxicity against mature red blood cells (RBCs), induces a schizont-stage arrest indistinguishable from that observed in imidazopyrazine-treated parasites and exhibits cross-resistance with the imidazopyrazine-resistant lines.

体内研究：

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