BIO,667463-62-9

公告提醒：爱必信所有产品和服务仅用于科学研究，不用于临床应用及其他用途提供产品和服务（也不为任何个人提供产品和服务）!

YZ剂描述：

产品名称：BIO

产品别名：(2'Z,3'E)-6-溴靛玉红-3'-肟

英文别名：6BIO;6-BIO;GSK 3 IX;GSK 3 Inhibitor IX;MLS 2052;MLS2052;GSK-3 Inhibitor IX;6-bromoindirubin-3-oxime

靶点：GSK-3

CAS：667463-62-9

纯度：＞98%

外观：red brown to purple solid

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months.

描述：

BIO是一种特异性的GSK-3YZ剂，无细胞试验中作用于GSK-3α/β的IC50为5 nM，比作用于CDK5选择性高16倍以上，也是一种泛JAKYZ剂。

溶解性：DMSO ：71 mg/mL (199.34 mM)
Ethanol：21 mg/mL (58.96 mM)

体外研究：

BIO is a specific inhibitor of glycogen synthase kinase-3 (GSK-3), with IC50 of 5 nM for GSK-3α/β, shows > 16-fold selectivity over CDK5. BIO interacts within the ATP binding pocket of these kinases, reduces β-catenin phosphorylation on a GSK-3-specific site in cellular models, closely mimicks Wnt signaling in Xenopus embryos. In human and mouse embryonic stem cells, BIO maintains the undifferentiated phenotype and sustains expression of the pluripotent state-specific transcription factors Oct-3/4, Rex-1 and Nanog. BIO-mediated Wnt activation is functionally reversible, as withdrawal of the compound leads to normal multidifferentiation programs in both human and mouse embryonic stem cells. BIO promotes proliferation in mammalian cardiomyocytes. 6BIO is also a pan-JAK inhibitor, with IC50 values of 0.03, 1.5, 8.0, 0.5 μM for TYK2, JAK1, JAK2 and JAK3, respectively. BIO selectively inhibits phosphorylation of STAT3 and induces apoptosis of human melanoma cells.

体内研究：BIO (50 mg/kg, p.o.) suppresses melanoma tumor growth in a mouse xenograft model.

产品信息订购：

产品更多信息请进入爱必信网站咨询