TCS JNK 5a,312917-14-9

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YZ剂描述：

产品名称：TCS JNK 5a

产品别名：JNK Inhibitor IX

英文别名：JNK Inhibitor IX;TCSJNK-5a

靶点：JNK3 ，JNK2

CAS：312917-14-9

纯度：>98%

外观：Powder

保存方法：store at -20℃ for one year（Powder）； in DMSO or others solvent store at 2-4℃ for two weeks, at -80℃ for six months.

描述：

TCS-JNK-5a is a selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38α respectively).

溶解性：DMSO : 33.2 mg/mL (100 mM)

体外研究：

JNK inhibitor IX significantly reduces caspase-3 activity by the inhibition of JNK activity in human dermal fibroblasts. JNK inhibition by JNK inhibitor IX significantly increases apoptotic death in response to imatinib mesylate (IM) by preventing c-ABL complete de-phosphorylation at Ser residues.

体内研究：

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