公告提醒:爱必信所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! YZ剂描述: 产品名称:SH-4-54 产品别名:SH454 英文别名:SH454 靶点:STAT CAS:1456632-40-8 纯度:>98% 外观:见爱必信官网 保存方法:store at -20℃ for one year(Powder); in DMSO or others solvent store at 2-4℃ for two weeks, at -20℃ for six months. 描述: SH-4-54 is a potent STAT inhibitor with KD of 300 nM and 464 nM for STAT3 and STAT5. 溶解性:DMSO100 mg/mL (163.77 mM) Ethanol50 mg/mL warmed (81.88 mM) Waterslightly soluble or insoluble
体外研究: SH-4-54在人恶性胶质瘤脑肿瘤肝细胞(BTSCs)中表现出的细胞毒性,而在人类胚胎星形胶质细胞中没有毒性。此外,SH-4-54有效YZSTAT3磷酸化和其下游转录靶点。 体内研究:SH-4-54 exhibits blood-brain barrier permeability potently controls glioma tumor growth, and inhibits pSTAT3 in vivo. SH-4-54 demonstrates the power of STAT3 inhibitors for the treatment of BTSCs and validates the therapeutic efficacy of a STAT3 inhibitor for GBM clinical application.SH-4-54 decreases pSTAT3 expression in tumor cells of treated mice. SH-4-54 appears to decrease proliferation and increase apoptosis of treated tumors. 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs811512 | SH-4-54 | 5mg | 1386 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |