Rabbit anti-Cullin2 Polyclonal Antibody,Cullin2抗体

抗体描述：

产品名称：Rabbit anti-Cullin2 Polyclonal Antibody

产品别名：Cul2; CUL 2; CUL-2; CUL2; CUL2_HUMAN; cullin 2; cullin homolog 2; Cullin-2; MGC131970;

特异性：Cullin 2 antibody detects endogenous levels of total Cullin 2.

来源：Rabbit

反应种属：Human, Mouse

克隆性：Polyclonal

保存方法：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles

产品描述：CUL2 Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).

用途范围： WB: 1:500~1:3000, IHC: 1:50~1:200, IF/ICC: 1:100~1:500, ELISA(peptide) 1:20000-1:40000

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