α1-chimaerin蛋白抗体,Anti-CHN 1抗体

产品名称：α1-chimaerin蛋白抗体,Anti-CHN 1抗体 
中文名称：α1-chimaerin蛋白抗体  
英文名称：Anti-CHN 1/Alpha-chimerin
产品编号：byk-11539R 
产品规格：0.1ml/0.2ml
产品用途：科研实验
亚 型： IgG
贮 存： 贮存于-20℃
抗体的异质性。抗体的组成极为复杂，是由成千上万、多种多样的免疫球蛋白（Ig）分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上，既相似，又有差别。由于有差别，它们的电泳活性就有很大的变化。
α1-chimaerin蛋白抗体,Anti-CHN 1抗体  品说明：
The Rac-GAP chimaerin family member Alpha-chimaerin (also known as N-chimaerin or rho GTPase-activating protein 2) has two splice variants: Alpha1 and Alpha2. The ?-chimaerin variant is a neuron-specific, diacylglycerol-binding and GTPase-activating protein for ras-related protein Rac 1. This variant lacks the N-terminal SH2 domain that is present in the Alpha2 variant. By inactivating Rac 1, Alpha1-chimaerin plays a significant role in the regulation of dendritic growth during neuronal development. It is recruited to the plasma membrane by phospholipase C Beta-coupled cell surface receptors activating the downstream generation of DAG (diacylglycerol). Overexpression of Alpha1-chimaerin results in dendritic spine retraction and the loss of dendritic branches. In the presence of reduced neuronal activity, Alpha1-chimaerin expression is down-regulated resulting in an increase in spine growth and dendritic branching.
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 
α1-chimaerin蛋白抗体,Anti-CHN 1抗体 关产品：
Anti-β-2-MG  鼠抗人β2微球蛋白抗体(单抗)
Anti-MOG(myelin oligo-dendrocyte glycoprotein-MOG)  髓鞘少树突胶质细胞糖蛋白抗体
Anti-Moesin抗体，膜突蛋白抗体
Anti-Mouse IgA  抗小鼠IgA抗体
Anti-MRAS/Mras  原癌基因M-ras抗体
Anti-MPO (myeloperoxidase) 髓过氧化物酶抗体
Anti-MR抗体，盐皮质激素受体抗体
Anti-MRP1抗体，多药耐药相关蛋白1抗体
Anti-MRP2抗体，多药耐药相关蛋白2抗体
Anti-MRP3抗体，多药耐药相关蛋白3抗体
抗体结构:
抗体是具有4条多肽链的对称结构，其中2条较长、相对分子量较大的相同的重链(H链)；2条较短、相对分子量较小的相同的轻链(L链)。链间由二硫键和非共价键联结形成一个由4条多肽链构成的单体分子。轻链有κ和λ两种，重链有μ、δ、γ、ε和α五种。 整个抗体分子可分为恒定区和可变区两部分。在给定的物种中，不同抗体分子的恒定区都具有相同的或几乎相同的氨基酸序列。可变区位于"Y"的两臂末端。在可变区内有一小部分氨基酸残基变化特别强烈，这些氨基酸的残基组成和排列顺序更易发生变异区域称高变区。高变区位于分子表面，多由17个氨基酸残基构成，少则只有2 ～ 3个。高变区氨基酸序列决定了该抗体结合抗原抗原的特异性。一个抗体分子上的两个抗原结合部位是相同的，位于两臂末端称抗原结合片段(antigen-binding fragment, Fab)。"Y"的柄部称结晶片段(crystalline fragment,FC)，糖结合在FC 上。