产品描述: 产品名称:Recombinant human Cytotoxic T-lymphocyte protein 4 (CTLA4) protein 产品别名:Cytotoxic T-lymphocyte protein 4 / CTLA4 形态:Protein is supplied in 20 mM Tris,150 mM NaCl, 10% Glycerol, pH 7.5 氨基酸序列:见爱必信官网 内毒素水平:见爱必信官网 活性:见爱必信官网 保存方法:Clear solution, frozen.Store at -70°C. At first use, aliquot and store at -70°C to avoid multiple freeze-thaws. 产品描述: Recombinant human CTLA4 protein aa 1-161 was produced in mammalian cells with C-terminal His-DYK tag. The theoretical molecular weight of recombinant CTLA4 is 15.6 kDa. Purified CTLA4 protein is below the position of 26 kDa on SDS-PAGE gel under reduced condition. CTLA4 protein is purified by proprietary chromatographic techniques. Entrez Gene summary for CTLA4: This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. UniProtKB/Swiss-Prot: P16410 (CTLA4_HUMAN) Function: Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. 预期分子量:见爱必信官网 产品信息订购: 产品货号 | 产品名称 | 规格 | 价格 | 大包装及货期 | abs02003 | Recombinant human Cytotoxic T-lymphocyte protein 4 (CTLA4) protein | 10ug | 600 | 立即咨询 | 产品更多信息请进入爱必信网站咨询 |