乙酰基赖氨酸/乙酰化赖氨酸抗体_详细资料

产品信息

货号： jlcR8850 保存条件： -20 ° 浓度： 1mg/ml 应用范围： WB,ELISA等适应物种：人/动物/植物抗体名：乙酰基赖氨酸/乙酰化赖氨酸抗体抗体英文名： Acetylated Lysine 保质期： 1年克隆性：单克隆数量： 134 供应商：江西江蓝纯生物试剂有限公司规格： 100ul

产品货号 :  jlcR8850
英文名称 :  Acetylated Lysine
中文名称 : 乙酰基赖氨酸/乙酰化赖氨酸抗体
别    名 :  Ac-lysine; Ac lysine; Ac-K; Ac K; Ac-Lys; Ac Lys; acetyl-Lysine; acetyl Lysine; acetyl-Lys; acetyl Lys.
产品类型 :  药物与化合物抗体乙酰化抗体
研究领域 :  细胞生物免疫学表观遗传学
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应 :  Ac-lysine
产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
细胞定位 :  细胞核
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/ml
免疫原 :  KLH conjugated synthetic peptide derived from human acetyl Lysine:
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储存液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed
产品介绍 :   In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation. The reversible lysine acetylation of histones and non-histone proteins plays a vital role in the regulation of many cellular processes including chromatin dynamics and transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. More than 20 acetyltransferases and 18 deacetylases have been identified so far, but the mechanistic details of substrate selection and site specificity of these enzymes remain unclear. Over 40 transcription factors and 30 other nuclear, cytoplasmic, bacterial, and viral proteins have been shown to be acetylated in vivo.

SWISS:
N/A

CAS:
692-04-6

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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