货号：
jlcR18644
保存条件：
-20 °
浓度：
1mg/ml
应用范围：
WB,ELISA等
适应物种：
人/动物/植物
抗体名：
内质网α-甘露糖苷酶1抗体
抗体英文名：
MAN1B1
保质期：
1年
克隆性：
单克隆
数量：
159
供应商：
江西江蓝纯生物试剂有限公司
规格：
100ul/200ul
| 规格： |
100ul |
产品价格： |
¥1580.0 |
| 规格： |
200ul |
产品价格： |
¥2480.0 |
产品货号 : jlcR18644英文名称 : MAN1B1中文名称 : 内质网α-甘露糖苷酶1抗体别 名 : Alpha 1 2 mannosidase; Endoplasmic reticulum alpha mannosidase 1; Endoplasmic reticulum mannosyl oligosaccharide 1 2 alpha mannosidase 1; Endoplasmic reticulum mannosyl oligosaccharide 1 2 alpha mannosidase; ER alpha 1 2 mannosidase; Man9GlcNAc2 specific processing alpha mannosidase; MANA ER; Mannosidase alpha class 1B member 1. 研究领域 : 细胞生物 免疫学 抗体来源 : Rabbit克隆类型 : Polyclonal交叉反应 : Human, Mouse, Rat, Pig, Horse, 产品应用 : ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.分 子 量 : 80kDa细胞定位 : 细胞浆 细胞膜 性 状 : Lyophilized or Liquid浓 度 : 1mg/ml免 疫 原 : KLH conjugated synthetic peptide derived from human MAN1B1:211-320/699 亚 型 : IgG纯化方法 : affinity purified by Protein A储 存 液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.PubMed : PubMed产品介绍 : This gene encodes an enzyme belonging to the glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis, and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2 in the endoplasmic-reticulum-associated degradation pathway. Mutations in this gene cause autosomal-recessive intellectual disability. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Dec 2011]Function:Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man5-6GlcNAc2.Subcellular Location:Endoplasmic reticulum membrane; Single-pass type II membrane protein.Tissue Specificity:Widely expressed.DISEASE:Mental retardation, autosomal recessive 15 (MRT15) [MIM:614202]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Note: The disease is caused by mutations affecting the gene represented in this entry. Similarity:Belongs to the glycosyl hydrolase 47 family. SWISS:Q9UKM7Gene ID:11253Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
