P Glycoprotein| P Glycoprotein antibody

Product Name P Glycoprotein antibody

Catalog No PAab09805

Packing 100ul

Form liquid

Alternative Name ABCB1, CD243, GP170, MDR1, Multidrug resistance protein 1, P glycoprotein 1

Purification Immunogen affinity purified

Purity 95% as determined by SDS-PAGE

Host Rabbit

Isotype IgG

Storage PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20Centigrade for 24 months (Avoid repeated freeze / thaw cycles.)

Background/ FUNCTION

ABCB1(also known as P-gp/ P-glycoprotein, MDR1/multidrug-resistance 1) is a plasma membrane protein first discovered in multidrug resistant tumor cells. ABCB1 can extrude a large number of medically relevant compounds from cells and causes drug resistance. ABCB1 is expressed in a variety of human cancers as well as normal tissues including brain, and placenta. Overexpression of ABCB1 correlates with a negative prognosis in several types of cancer.

Immunogen ABCB1

Specificity Human, Mouse

Tested Application ELISA, WB, IP, IHC

Recommended dilution WB: 1:200-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500

IHC use Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using PAab09805(P glycoprotein antibody) at dilution of 1:500

WB use

HepG2 cells were subjected to SDS PAGE followed by western blot with PAab09805(P glycoprotein antibody) at dilution of 1:300

Protein Information

Gene ID

Uniprot ID P08183

Calculated MW 173 kDa

Research Area Neuroscience, Immunology, Metabolism