Phospho-PTEN(S380)

【Molecular Wt.】55 kDa

【Description】As human tumors progress to advanced stages, one genetic alteration that occurs at high frequency is a loss of heterozygosity (LOH) at chromosome 10q23. Mapping of homozygous deletions on this chromosome led to the isolation of the PTEN gene, also designated MMAC1 (for mutated in multiple advanced cancers) and TEP1. This candidate tumor suppressor gene exhibits a high frequency of mutations in human glioblastomas and is also mutated in other cancers, including sporadic brain, breast, kidney and prostate cancers. PTEN has been associated with Cowden disease, an autosomal dominant cancer predisposition syndrome. The PTEN gene product is a putative protein tyrosine phosphatase that is localized to the cytoplasm and shares extensive homology with the cytoskeletal proteins tensin and auxilin. Gene transfer studies have indicated that the phosphatase domain of PTEN is essential for growth suppression of glioma cells.

【Species Reactivity】Human;Mouse;Rat

【Tested applications】WB;ICC

【Antibody type】Recombinant Rabbit monoclonal Antibody

【Immunogen】Synthetic phospho-peptide corresponding to residues surrounding Ser380 of human PTEN.

【Positive control】SW480, MCF-7, Hela, human placenta tissue, human lung tissue.

【Conjugate】Non-conjugated

【Alternative names】10q23del antibody
BZS antibody
DEC antibody
GLM2 antibody
MGC11227 antibody
MHAM antibody
MMAC1 antibody
MMAC1 phosphatase and tensin homolog deleted on chromosome 10 antibody
Mutated in multiple advanced cancers 1 antibody
Phosphatase and tensin homolog antibody
Phosphatase and tensin like protein antibody
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN antibody
Pten antibody
PTEN_HUMAN antibody
PTEN1 antibody
TEP1 antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Protein A purified.

【Subcellular location】Cytoplasm, Nucleus, Secreted.

【Background References】1. Ma J et al. microRNA-22 attenuates neuronal cell apoptosis in a cell model of traumatic brain injury. Am J Transl Res 8:1895-902 (2016).
2. Chang H et al. EGFR protein expression using a specific intracellular domain antibody and PTEN and clinical outcomes in squamous cell lung cancer patients with EGFR-tyrosine kinase inhibitor therapy. Onco Targets Ther 9:5153-62 (2016).

【DatasheetURL】https://www.huabio.com/upload/ET1701-46.pdf

【Uniprot ID】P60484(Human) O08586(Mouse)

【Raised in】Rabbit

【Clone No.】JJ08-81