Neuron-specific class Ⅲ β-tubulin

【Molecular Wt.】50 kDa

【Description】Tubulin is a compound of subunits of A tubulin and B tubulin. Class III beta tubulin (beta III-tubulin) is a vertebrate tubulin isotype specific to the neurons and mammalian testis cells, making it an ideal neuronal marker. Overexpression of class III beta tubulin is associated with the resistances of microtubule-targeted cancer drugs in lung cancer cell lines, breast cancer cell lines, and ovarian tumors.

【Species Reactivity】Human;Mouse;Rat

【Tested applications】WB;ICC;IHC;FC

【Antibody type】Rabbit polyclonal Antibody

【Immunogen】This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to a region of N-terminal residues of tubulin beta-3.

【Positive control】Hela, HepG2, NIH-3T3, rat brain tissue, rat kidney tissue, human colon cancer tissue.

【Conjugate】Non-conjugated

【Alternative names】beta 3 tubulin antibody
beta-4 antibody
CDCBM antibody
CDCBM1 antibody
CFEOM3 antibody
CFEOM3A antibody
FEOM3 antibody
M(beta)3 antibody
M(beta)6 antibody
MC1R antibody
Neuron specific beta III Tubulin antibody
Neuron-specific class III beta-tubulin antibody
QccE-11995 antibody
QccE-15186 antibody
TBB3_HUMAN antibody
Tubb 3 antibody
TUBB3 antibody
TUBB4 antibody
Tubulin beta 3 antibody
Tubulin beta 3 chain antibody
Tubulin beta 4 antibody
Tubulin beta III antibody
Tubulin beta-3 chain antibody
Tubulin beta-4 chain antibody
Tubulin beta-III antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 25%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Peptide affinity purified.

【Subcellular location】Cytoplasm. Cytoskeleton. Microtubule.

【Background References】1. Tischfield M A et al. Human TUBB3 mutations perturb microtubule dynamics, kinesin interactions, and axon guidance. Cell 140:74-87 (2010).
2. Poirier K et al. Mutations in the neuronal ss-tubulin subunit TUBB3 result in malformation of cortical development and neuronal migration defects. Hum Mol Genet 19:4462-4473 (2010).

【DatasheetURL】https://www.huabio.com/upload/0805-3.pdf

【Uniprot ID】Q13509(Human) Q9ERD7(Mouse) Q4QRB4(Rat)

【Raised in】Rabbit

【Clone No.】