α-Actin (cardiac actin)

【Molecular Wt.】42 kDa

【Description】Actins are highly conserved proteins expressed in all eucaryotic cells. Actin filaments form part of the cytoskeleton and play essential roles in regulating cell shape and movement. Six distinct actin isotypes have been identified in mammalian cells. Each is encoded by a separated gene and is expressed in a developmentally regulated and tissue-specific manner, alpha and beta cytoplasmic actins are expressed in a wide variety of cells; whereas, expression of alpha skeletal, alpha cardiac, alpha vascular, and gamma enteric actins are more restricted to specialized muscle cell type. Smooth muscle alpha actin is of further interest because it is one of a few genes whose expression is relatively restricted to vascular smooth muscle cells. Further more, expression of smooth muscle alpha actin is regulated by hormones, cell proliferation , and altered by pathological conditions including oncogenic transformation and atherosclerosis

【Species Reactivity】Human;mouse;rat;zebrafish

【Tested applications】WB;ICC;IHC;FC

【Antibody type】Rabbit polyclonal Antibody

【Immunogen】peptide

【Positive control】Mouse heart

【Conjugate】Non-conjugated

【Alternative names】ACTC antibody
ACTC_HUMAN antibody
ACTC1 antibody
Actin alpha cardiac muscle 1 antibody
Actin antibody
alpha cardiac muscle 1 antibody
Alpha-cardiac actin antibody
ASD5 antibody
CMD1R antibody
CMH11 antibody
LVNC4 antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Immunogen affinity purified

【Subcellular location】Cytoplasma , etc.

【Background References】1. The MGC Project Team. Genome Res. 14:2121-2127(2004).
2. Leader D.P., Gall I., Campbell P.C. Biosci. Rep. 6:741-747(1986).
3. Carninci P., Kasukawa T., Katayama S.etc. Science 309:1559-1563(2005).

【DatasheetURL】https://www.huabio.com/upload/0407-3.pdf

【Uniprot ID】P68032

【Raised in】Rabbit

【Clone No.】