【Molecular Wt.】190 kDa
【Description】Platelet Derived Growth Factor (PDGF) is a mitogen for mesenchyme- and glia-derived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PDGF-AA, PDGF-AB, and PDGF-BB. These three isoforms bind with different affinities to two receptor types, a and b, which are endowed with protein tyrosine kinase domains and undergo either homo- or heterodimerization as a consequence of ligand binding. Ligand stimulation of PDGFR-b leads to autophosphorylation at Tyr-857, which is the major autophosphorylation site, and Tyr-751, which is the major in vitro phosphorylation site. Autophosphorylation of Tyr-751, which lies in the kinase insert region, is required for binding of phosphatidylinositol-3 kinase to the receptor. These auto-phosphorylation events largely contribute to signal transduction through the PDGF receptor.
【Species Reactivity】Mouse;Rat
【Tested applications】WB;ICC/IF
【Antibody type】Recombinant Rabbit monoclonal Antibody
【Immunogen】Synthetic phospho-peptide corresponding to residues surrounding Tyr740 of human PDGF Receptor beta.
【Positive control】C2C12, Hela, L6.
【Conjugate】Non-conjugated
【Alternative names】Beta platelet derived growth factor receptor antibody
Beta-type platelet-derived growth factor receptor antibody
CD 140B antibody
CD140 antigen-like family member B antibody
CD140b antibody
CD140b antigen antibody
IBGC4 antibody
IMF1 antibody
JTK12 antibody
OTTHUMP00000160528 antibody
PDGF R beta antibody
PDGF-R-beta antibody
PDGFR 1 antibody
PDGFR antibody
PDGFR beta antibody
PDGFR1 antibody
PDGFRB antibody
PGFRB_HUMAN antibody
Platelet derived growth factor receptor 1 antibody
Platelet derived growth factor receptor beta antibody
Platelet derived growth factor receptor beta polypeptide antibody
【Form】Liquid
【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
【Isotype】IgG
【Purity】Protein A purified.
【Subcellular location】Cell membrane, Cytoplasmic vesicle.
【Background References】1. Kumar, A. et al. 2010. Platelet-derived growth factor-DD targeting arrests pathological angiogenesis by modulating glycogen synthase kinase-3beta phosphorylation. J. Biol. Chem. 285: 15500-15510.
2. Siegbahn, A. et al. 2008. TF/FVIIa transactivate PDGFRbeta to regulate PDGF-BB-induced chemotaxis in different cell types: involvement of Src and PLC. Arterioscler. Thromb. Vasc. Biol. 28: 135-141.
【DatasheetURL】https://www.huabio.com/upload/ET1611-29.pdf
【Uniprot ID】P05622(Mouse) Q05030(Rat)
【Raised in】Rabbit
【Clone No.】SN0646