胰岛素降解酶抗体,Anti-IDE抗体

抗原修复——原因 *常规的石蜡切片标本均用甲醛固定，结果使得： -抗原性物质形成醛键、羧甲键而被封闭了部分抗原决定簇； -蛋白之间发生交联而使抗原决定簇隐蔽。 *要求：在染色时，需要先进行抗原修复或暴露，即将固定时分子之间所形成的交联破坏，而恢复抗原的原有空间形态抗原修复——方法 *化学方法 *加热方法 -水浴加热法 -微波照射法 -高压加热法 -酸水解法
抗体（antibody）指机体的免疫系统在抗原刺激下，由B淋巴细胞或记忆细胞增殖分化成的浆细胞所产生的、可与相应抗原发生特异性结合的免疫球蛋白。主要分布在血清中，也分布于组织液及外分泌液中。
产品名称：胰岛素降解酶抗体,Anti-IDE抗体优货销售  
中文名称：胰岛素降解酶抗体 
英文名称：Anti-IDE    
产品编号：byk-0018M  
产品规格：0.1ml/0.2ml
产品用途：科研实验
性 状： Lyophilized or Liquid
浓 度： 1mg/1ml
亚 型： IgG
贮 存： 贮存于-20℃.
相关标记: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
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干扰素-gamma受体1抗体 Anti-IFNGR1/CD119
干扰素-γ/IFN-γ抗体 Anti-IFN gamma
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干扰素β抗体 Anti-IFN-β
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神经母细胞瘤蛋白PHOX2B抗体 Anti-PHOX2B
干扰素α抗体 Anti-IFN-Alpha/IFNA1/IFNA13/Interferon alpha 1
干扰素β抗体 Anti-IFN-Beta
双链RNA结合蛋白Staufen2抗体 Anti-STAU2
干扰素诱导跨膜蛋白1抗体 Anti-IFITM1/CD225
Kartagener综合征相关蛋白RSHL3抗体 Anti-RSPH4A/RSHL3
γ干扰素诱导蛋白16抗体 Anti-IFI16/MNDA
小肠型脂肪酸结合蛋白抗体 Anti-IFABP/FABP2
胰岛素降解酶抗体 Anti-IDE
诱导协同刺激分子CD278抗体 Anti-ICOS/CD278
磷酸化β-连环蛋白/β-连环素/β链接素抗体 Anti-phospho-beta Catenin (Ser33)
Caspase激活的脱氧核糖核酸酶YZ剂抗体 Anti-ICAD/DFF-45 Beta
突触相关蛋白29抗体 Anti-SNAP29
离子钙接头蛋白抗体 Anti-AIF1/IBa-1
胰岛素降解酶抗体,Anti-IDE抗体优货销售 产品详情：
绍 Insulysin was identified nearly a century ago as an enzyme responsible for the degradation of insulin in cells, although the precise interactions between insulin and insulysin remain elusive. Human insulysin was cloned in 1988, and shown to be a 118 kDa protein that exists primarily as a homodimer, and perhaps also complexed with other molecules. The sequence is well conserved between humans, rats and mice, and the antibody recognizes these species. Insulysin is a metalloproteinase of the clan ME, family M16, which contains an active site HxxEH, a reversal of the canonical HExxH zinc binding motif. Considered a zinc metalloproteinase, the activity of insulysin can be blocked with EDTA or 1-10 phenanthroline. In addition to the active metalloproteinase domain, insulysin contains a second metalloproteinase site which is considered catalytically inactive, and is thought to assist in substrate binding. Insulysin is most closely related to the bacterial proteinase pitrilysin, (the human orthologue of which appears to be MPRP1) and the mammalian proteinsae nardilysin. Generally thought to be a cytoplasmic protein, insulysin has been isolated from many different tissues and cell lines, and can degrade intact insulin, insulin B chain, glucagon, denatured hemoglobin, alpha amyloid protein, TGF alpha and amylin. Recent work implicates insulysin in clearing beta amyloid plaques from the brain, and has generated much interest in Alzheimer’s disease research. The pH optimum for insulysin is basic, pH 8.5, which also distinguishes it from other metalloproteinases
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抗体是具有4条多肽链的对称结构，其中2条较长、相对分子量较大的相同的重链（H链）；2条较短、相对分子量较小的相同的轻链（L链）。链间由二硫键和非共价键联结形成一个由4条多肽链构成的单体分子。轻链有κ和λ两种，重链有μ、δ、γ、ε和α五种。 整个抗体分子可分为恒定区和可变区两部分。在给定的物种中，不同抗体分子的恒定区都具有相同的或几乎相同的氨基酸序列。可变区位于"Y"的两臂末端。在可变区内有一小部分氨基酸残基变化特别强烈，这些氨基酸的残基组成和排列顺序更易发生变异区域称高变区。高变区位于分子表面，多由17个氨基酸残基构成，少则只有2 ～ 3个。高变区氨基酸序列决定了该抗体结合抗原抗原的特异性。一个抗体分子上的两个抗原结合部位是相同的，位于两臂末端称抗原结合片段（antigen-binding fragment, Fab）。"Y"的柄部称结晶片段（crystalline fragment,FC），糖结合在FC 上。