BD™ P100 Blood Collection System (16x100 mm / 8.5 mL)
- Tube MaterialPlastic
- Tube Size16x100 mm
- Draw Volume8.5 mL
- Closure TypeBD Hemogard™
- Closure ColorClear
- LabelPaper
- Cell SeparatorYes (Mechanical)
- AnticoagulantK2EDTA
- AdditiveProprietary Protein Stabilizers
- SterilizationRadiation , 10-6 SAL , ISO11137-1
Description
Human plasma contains a wide variety of proteins that hold potential as biomarkers for proteomics-based diagnostic and prognostic assays. These proteins are subject to proteolytic degradation and modification during and after blood collection.
The BD™ P100 blood collection tubes minimize preanalytical variability in plasma protein analysis. The tubes are spray coated with K2EDTA anticoagulant and proprietary protease inhibitor cocktail, specifically formulated for stabilization of human plasma proteins at the point of collection. Inclusion of a novel mechanical separator within the 8.5 mL BD™ P100 Tubes provides better separation of cellular components from plasma than gel-based separators.
BD™ P100 is for research use only – it is not for use in diagnostic procedures.
PREPARATION AND STORAGE
Store tubes at 4-25 ºC (39-77 ºF) unless otherwise noted on the package label. It is recommended to store the tubes in the original sealed packaging until use. The pouch with desiccant provides a moisture barrier to preserve the potency of the additives.
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Craft D, Yi J, Gelfand CA. Time-dependent and Sample-to-sample Variations in Human Plasma Peptidome are both minimised through use of Protease Inhibitors. Analytical Letters 2009;2:1398-1406.
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Roy M. Controlled Analysis of Preanalytical Variables in CSF and Blood Sample Collection, Processing and Storage: Implications for Best Practices in Clinical Research. Presented at ISBER, Orlando, FL, 2014.
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Waters J, Dhere V, Benjamin A, Sekar A, Kumar A, Prahalad S, Okou DT, Kugathasan S. A Practical and Novel Method to Extract Genomic DNA from Blood Collection Kits for Plasma Protein Preservation. J Vis Exp. 2013; 75:e4241.
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Yi J, Craft D, Gelfand CA. Minimising Preanalytical and Analytical Variability in Plasma Peptidomics using MALDI-TOF MS. Methods Mol Biol 2011;728:137-149.
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Yi J, et al. Inhibition of Intrinsic Proteolytic Activities Moderates Preanalytical Variability and Instability of Human Plasma. J Proteomic Res 2007;6:1768-1781.
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Yi J, Liu Z, Craft D, O'Mullan P, Ju G, Gelfand CA. Intrinsic Peptidase Activity Causes a Sequential Multi-step Reaction (SMSR) in Digestion of Human Plasma Peptides. J Proteomic Res 2008;7:5112-5118.
资料下载:
PI_P100_366448_VDP40144-03_P100_500008062_PC_web.pdf
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