ubiquitin| ubiquitin antibody

货号  PAab09197

蛋白别名  FLJ25987 antibody, Polyubiquitin B antibody, UBB antibody, ubiquitin antibody, ubiquitin B

蛋白介绍

Ubiquitin B (UBB) is a member of ubiquitin family, one of the most conserved proteins known. Ubiquitin B is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin B is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression.When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein has been noticed in patients with Alzheimer's and Down syndrome. Interestingly ubiquitin also becomes covalently bonded to many types of pathological inclusions which appear to be resistant to normal degradation.

产品描述

建议稀释比例

WB : 1:200-1:2000;IP:1:200-1:1000;IHC:1:50-1:200

IHC

Immunohistochemistry of paraffin-embedded human pancreas using PAab09197(ubiquitin antibody) at dilution of 1:50

Western blot

MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with PAab09197( ubiquitin Antibody) at dilution of 1:600(本抗体仅供体外科研用途，不可用于临床诊断!)

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