TRIM24| TRIM24 antibody

货号  PAab08975

蛋白别名  HTIF1 antibody, PTC6 antibody, RING finger protein 82 antibody, RNF82 antibody, TF1A antibody, TIF1 antibody, TIF1 alpha antibody, TIF1A antibody, TIF1ALPHA antibody, TRIM24 antibody, tripartite motif containing 24

蛋白介绍

Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity).

产品描述

建议稀释比例

WB:1:500-1:5000;IP:1:200-1:2000;IHC:1:50-1:200;IF:1:50-1:500

IHC

Immunohistochemistry of paraffin-embedded human prostate cancer using PAab08975(TRIM24 antibody) at dilution of 1:100

Western blot

HeLa cells were subjected to SDS PAGE followed by western blot with PAab08975(TRIM24 antibody) at dilution of 1:500(本抗体仅供体外科研用途，不可用于临床诊断!)

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