NUMBL| NUMBL antibody

货号  PAab05918

蛋白别名  

蛋白介绍

Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF- kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.

产品描述

建议稀释比例

IHC

Immunohistochemistry of paraffin-embedded human gliomas tissue slide using PAab05918( NUMBLIKE Antibody) at dilution of 1:50

Western blot

L02 cells were subjected to SDS PAGE followed by western blot with PAab05918( NUMBLIKE Antibody) at dilution of 1:1000(本抗体仅供体外科研用途，不可用于临床诊断!)

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