产品名称:丝裂原活化蛋白激酶激酶激酶4抗体,Anti-MAP3K4抗体
中文名称:丝裂原活化蛋白激酶激酶激酶4抗体
英文名称:Anti-MAP3K4
产品编号:byk-11883R
产品规格:0.1ml/0.2ml
产品用途:科研实验
性 状: Lyophilized or Liquid
浓 度: 1mg/1ml
亚 型: IgG
贮 存: 贮存于-20℃.
相关标记: HRP Biotin Gold RBITC AP FITC Cy3 Cy5 Cy5.5 Cy7 PE PE-Cy3 PE-CY5 PE-CY5.5 PE-CY7 APC Alexa Fluor 350 Alexa Fluor 488 Alexa Fluor 555 Alexa Fluor 647
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抗体规律
(1)初次反应产生抗体:当抗原一次进入机体时,需经一定的潜伏期才能产生抗体,且抗体产生的量也不多,在体内维持的时间也较短。
(2)再次反应产生抗体:当相同抗原第二次进入机体后,开始时,由于原有抗体中的一部分与再次进入的抗原结合,可使原有抗体量略为降低。随后,抗体效价迅速大量增加,可比初次反应产生的多几倍到几十倍,在体内留存的时间亦较长。
(3)回忆反应产生抗体:由抗原刺激机体产生的抗体,经过一定时间后可逐渐消失。此时若再次接触抗原,可使已消失的抗体快速上升。如再次刺激机体的抗原与初次相同,则称为特异性回忆反应;若与初次反应不同,则称为非特异性回忆反应。非特异性回忆反应引起的抗体的上升是暂时性的,短时间内即很快下降。
丝裂原活化蛋白激酶激酶激酶4抗体,Anti-MAP3K4抗体 产品详情:
The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.