品名 | anti- E-cadherin antibody |
货号 | FNab10112 |
规格 | 100µg |
状态 | liquid |
纯化方法 | protein A+G purified |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Mouse |
亚型 | IgG2b |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. |
免疫原 | cadherin 1, type 1, E-cadherin (epithelial) |
别称 | Arc 1, Cadherin 1, CD324, CDH1, CDHE, E cadherin, ECAD, E-cadherin, LCAM, UVO, Uvomorulin |
分子量 | 130 kDa |
Uniprot ID | P12830 |
适用种属 | Human |
验证应用 | ELISA, IHC, WB, IF |
建议稀释比例 | WB: 1:1000-1:5000; IHC: 1:500-1:2000; IF: 1:50-1:500 |
图片 | ![](http://item.yiqi.com/pic/ConPic/4/FNab10112.jpg) | Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab10112( E-cadherin Antibody) at dilution of 1:1000 |
![](http://item.yiqi.com/pic/ConPic/4/FNab10112.jpg) | A431 cells were subjected to SDS PAGE followed by western blot with FNab10112(E-cadherin antibody) at dilution of 1:3000 |
注意事项 | E-cadherin antibody|E-cadherin抗体仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab10112/ |