T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体_详细资料

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货号： jlcR9428 保存条件： -20 ° 浓度： 1mg/ml 应用范围： WB,ELISA等适应物种：人/动物/植物抗体名： T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体抗体英文名： Tal1 保质期： 1年克隆性：单克隆数量： 184 供应商：江西江蓝纯生物试剂有限公司规格： 100ul/200ul

规格： 100ul 产品价格： ¥1580.0

规格： 200ul 产品价格： ¥2480.0

产品货号 :  jlcR9428
英文名称 :  Tal1
中文名称 :  T细胞急性淋巴细胞性白血病1蛋白/淋巴瘤蛋白5抗体
别    名 :  bHLHa17; Class A basic helix-loop-helix protein 17; SCL antibody; Stem cell protein; T cell acute lymphocytic leukemia 1; T cell acute lymphocytic leukemia 1 protein; T cell leukemia/lymphoma 5 protein; T-cell acute lymphocytic leukemia protein 1; T-cell leukemia/lymphoma protein 5; Tal 1; Tal 1 product; TAL 1 protein; TAL-1; tal1; TAL1_HUMAN; TCL 5; TCL5.
研究领域 :  肿瘤细胞生物发育生物学信号转导干细胞细胞周期蛋白细胞分化表观遗传学
抗体来源 :  Rabbit
克隆类型 :  Polyclonal
交叉反应 :   Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit,
产品应用 :  ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量 :  34kDa
细胞定位 :  细胞核
性    状 :  Lyophilized or Liquid
浓    度 :  1mg/ml
免疫原 :  KLH conjugated synthetic peptide derived from human Tal1:185-300/331
亚    型 :  IgG
纯化方法 :  affinity purified by Protein A
储存液 :  0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 :  Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :  PubMed
产品介绍background :
Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIalpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.

Function:
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity).

Subunit:
Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.

Subcellular Location:
Nucleus.

Tissue Specificity:
Leukemic stem cell.

Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.

SWISS:
P17542

Gene ID:
6886

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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规格：	100ul	产品价格：	¥1580.0
规格：	200ul	产品价格：	¥2480.0

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