品名 | anti- APP(C-Terminal)antibody |
货号 | FNab00512 |
规格 | 100µg |
状态 | liquid |
纯化方法 | Immunogen affinity purified |
纯度 | ≥95% as determined by SDS-PAGE |
宿主 | Rabbit |
亚型 | IgG |
存储 | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 24 months(Avoid repeated freeze / thaw cycles.) |
背景介绍 | This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. |
免疫原 | amyloid beta A4 precursor protein |
别称 | A4, ABPP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide, Beta-amyloid precursor protein, CVAP, PreA4 |
分子量 | 110 kDa |
Uniprot ID | P05067 |
适用种属 | Human, Mouse, Rat |
验证应用 | ELISA, WB, IHC |
建议稀释比例 | WB: 1:500 - 1:2000; IHC: 1:50 - 1:100 |
图片 |  | Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab00512( APP Antibody) at dilution of 1:100 |
 | HeLa cells cells were subjected to SDS PAGE followed by western blot with FNab00512( APP Antibody) at dilution of 1:1000 |
注意事项 | APP(C-Terminal)antibody|APP(C-Terminal)antibody仅供科研使用 |
产品链接 | https://www.fn-test.cn/product/FNab00512/ |